DIFFERENCES IN SENSITIVITY TO FARNESOL TOXICITY BETWEEN NEOPLASTICALLY-DERIVED AND NON-NEOPLASTICALLY-DERIVED CELLS IN CULTURE

被引：54
作者：
ADANY, I
YAZLOVITSKAYA, EM
HAUG, JS
VOZIYAN, PA
MELNYKOVYCH, G
机构：
[1] UNIV KANSAS,MED CTR,DEPT MICROBIOL MOLEC GENET & IMMUNOL,KANSAS CITY,KS 66103
[2] DEPT VET AFFAIRS MED CTR,RES SERV,KANSAS CITY,MO 64128
来源：
CANCER LETTERS | 1994年 / 79卷 / 02期
关键词：
FARNESOL; TOXICOLOGY; CELL CULTURES;
D O I：
10.1016/0304-3835(94)90257-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Six neoplastically-derived cell lines and three cell lines derived from normal tissues were compared for their sensitivity to isoprenoid irons-trans farnesol. Assays of cell numbers and of protein concentrations per culture revealed greater sensitivity of neoplastic cells than of the normal cells. Similar differences were obtained from the comparison of incorporation of [methyl-H-3]choline into cellular lipids, with neoplastic cells showing greater inhibition than normal cells.
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收藏
页码：175 / 179
页数：5
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