ROLE OF THYMUS-EICOSANOIDS IN THE IMMUNE-RESPONSE

被引：30

作者：

JUZAN, M ^{[1
]}

HOSTEIN, I ^{[1
]}

GUALDE, N ^{[1
]}

机构：

[1] FDN BERGONIE, F-33076 BORDEAUX, FRANCE

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1992年 / 46卷 / 04期

关键词：

D O I：

10.1016/0952-3278(92)90030-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present review deals with the role(s) of thymus-eicosanoids in the immune response. It reports the production of cyclooxygenase and lipoxygenase metabolites of arachidonic acid by cells of the thymus microenvironment and the role(s) of these eicosanoids in the differentiation and the maturation of immature T-cells. The possibility that these products may be involved in tolerance to self is discussed. Briefly, it is likely that cells from the monocyte-macrophage lineage which constitute a part of the thymus microenvironment could contribute to the education of immature thymocytes by both presenting self-antigens and producing eicosanoids. Tolerance to self might result from PGE2-driven apoptosis and/or LTB4-induced generation of suppressor cells.

引用

页码：247 / 255

页数：9

共 112 条

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