PYRIMIDO[1,6-A]BENZIMIDAZOLES - A NEW CLASS OF DNA GYRASE INHIBITORS

被引：59

作者：

HUBSCHWERLEN, C ^{[1
]}

PFLIEGER, P ^{[1
]}

SPECKLIN, JL ^{[1
]}

GUBERNATOR, K ^{[1
]}

GMUNDER, H ^{[1
]}

ANGEHRN, P ^{[1
]}

KOMPIS, I ^{[1
]}

机构：

[1] F HOFFMANN LA ROCHE LTD, PRECLIN RES, DIV PHARMA, CH-4002 BASEL, SWITZERLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 35卷 / 08期

关键词：

D O I：

10.1021/jm00086a006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Substituted 4-quinolone- (1, A = CH) and 1,8-naphthyrid-4-one- (1, A = N) 3-carboxylic acids are currently the only classes of clinically useful antibacterial agents exerting their activity by inhibiting the subunit A of DNA gyrase. Pyrimido[1,6-a]benzimidazoles 11 have been found to be a new class of inhibitors of this enzyme. The design, synthesis, and biological activity of these compounds are reported.

引用

页码：1385 / 1392

页数：8

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