SITE-SPECIFIC METHYLATION OF 16S RIBOSOMAL-RNA CAUSED BY PCT, A PACTAMYCIN RESISTANCE DETERMINANT FROM THE PRODUCING ORGANISM, STREPTOMYCES-PACTUM

被引：31

作者：

BALLESTA, JPG

CUNDLIFFE, E

机构：

[1] CSIC,CTR BIOL MOLEC,MADRID 6,SPAIN

[2] UNIV LEICESTER,DEPT BIOCHEM,LEICESTER LE1 7RH,ENGLAND

来源：

JOURNAL OF BACTERIOLOGY | 1991年 / 173卷 / 22期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/jb.173.22.7213-7218.1991

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ribosomal resistance to pactamycin in clones of Streptomyces lividans containing DNA (pct) from Streptomyces pactum, the pactamycin producer, involves methylation of 16S RNA. The modified residue A-941 in S. lividans 16S rRNA (A-964 in the homologous Escherichia coli sequence) is converted to 1-methyladenosine, and the ribosomal ability to bind pactamycin is reduced or abolished.

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页码：7213 / 7218

页数：6

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