MODIFICATIONS IN TISSUE HISTAMINE LEVELS IN MICE TREATED WITH CHRONIC EPICUTANEOUS APPLICATION OF PHORBOL-12-MYRISTATE-13-ACETATE

被引：0
作者：
PONVERT, C
BURTIN, C
CANU, P
PAUPE, J
机构：
[1] INSERM, U200, Laboratoire de Médecine Expérimentale et d'Immunologie (Pr. J. Paupe), Faculté de Médecine Necker-Enfants Malades, Paris, 75015
来源：
AGENTS AND ACTIONS | 1992年 / 35卷 / 3-4期
关键词：
D O I：
10.1007/BF01997494
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Chronic epicutaneous application of phorbol-12-myristate-13-acetate (PMA) on the right flank of C 57 BL/6 mice induces an inflammatory reaction and a selective increase in skin histamine level at the site of treatment. Tissue histamine levels were not increased at other sites such as controlateral skin, stomach rumen and skeletal muscle, and were decreased in stomach fundus and dorsal skin. These results are in agreement with the hypothesis that mast cells play a significant role in cutaneous inflammation induced by PMA.
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页码：159 / 162
页数：4
相关论文
共 25 条
[1]   T-CELL-DEPENDENT MAST-CELL DE-GRANULATION AND RELEASE OF SEROTONIN IN MURINE DELAYED-TYPE HYPERSENSITIVITY [J].
ASKENASE, PW ;
BURSZTAJN, S ;
GERSHON, MD ;
GERSHON, RK .
JOURNAL OF EXPERIMENTAL MEDICINE, 1980, 152 (05) :1358-1374
[2]  
Baggiolini M, 1984, Contemp Top Immunobiol, V14, P221
[3]  
Boutwell R K, 1974, CRC Crit Rev Toxicol, V2, P419
[4]   INCREASED TISSUE HISTAMINE IN TUMOR-BEARING MICE AND RATS [J].
BURTIN, C ;
SCHEINMANN, P ;
SALOMON, JC ;
LESPINATS, G ;
FRAYSSINET, C ;
LEBEL, B ;
CANU, P .
BRITISH JOURNAL OF CANCER, 1981, 43 (05) :684-688
[5]  
CORDON JR, 1990, BLOOD, V75, P1637
[6]   CELLULAR AND VASCULAR MANIFESTATIONS OF CELL-MEDIATED-IMMUNITY [J].
DVORAK, HF ;
GALLI, SJ ;
DVORAK, AM .
HUMAN PATHOLOGY, 1986, 17 (02) :122-137
[7]  
GALLI SJ, 1989, MAST CELL BASOPHIL D, P255
[8]   TISSUE HISTAMINE LEVELS AND MAST-CELL NUMBERS IN TUMOR-BEARING MICE [J].
GALOPPIN, L ;
RAYNAUD, F ;
PONVERT, C ;
FRAY, A ;
SCHEINMANN, P ;
LESPINATS, G ;
CANU, P ;
BURTIN, C .
AGENTS AND ACTIONS, 1984, 14 (3-4) :494-496
[9]  
GARSSEN J, 1989, IMMUNOLOGY, V68, P51
[10]  
Goldstein I M, 1984, Contemp Top Immunobiol, V14, P189
123