The Polarographic Reduction and Electrode Kinetics of Antidepressant Drug Bupropion Hydrochloride

The electroreduction of the antidepressant drug Bupropion hydrochloride has been studied in aqueous media at dme. Single well defined wave was obtained in different supporting electrolytes, like, KNO3, ammonium citrate buffer, acetate buffer, B. R. buffer, etc. The effect of pH on this reduction has been studied in B. R. buffer in the pH range 3.13 - 11.0. The Bupropion hydrochloride is best reduced in slightly acidic medium. This behavior was attributed to the reduction of >C=O group present in the drug. The effect of concentration and temperature on half wave potential has also been investigated. The reduction of drug was found to be irreversible and diffusion controlled, hence kinetic parameters (K-0 fh, alpha(n)) are evaluated using Meites Israel and Gaur Bharagav, s method. Further, with increase in temperature the values of K-0 fh also increase, showing that irreversibility of the system decreases on increasing the temperature.