METABOLISM OF STRYCHNINE N-OXIDE AND BRUCINE N-OXIDE BY HUMAN INTESTINAL BACTERIA

被引:16
作者
ELMEKKAWY, S [1 ]
MESELHY, MR [1 ]
KAWATA, Y [1 ]
KADOTA, S [1 ]
HATTORI, M [1 ]
NAMBA, T [1 ]
机构
[1] TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU,2630 SUGITANI,TOYAMA,TOYAMA 93001,JAPAN
关键词
STRYCHNINE N-OXIDE; BRUCINE N-OXIDE; METABOLISM; LACTOBACILLUS-ACIDOPHILUS; STRYCHNINE; 16-HYDROXYSTRYCHNINE; BRUCINE; 16-HYDROXYBRUCINE; STRYCHNOS-NUX-VOMICA; LOGANIACEAE;
D O I
10.1055/s-2006-959698
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Anaerobic incubation of strychnine N-oxide with human intestinal bacteria resulted in its transformation to strychnine and 16-hydroxystrychnine. Similarly, brucine N-oxide was transformed to brucine and 16-hydroxybrucine.
引用
收藏
页码:347 / 350
页数:4
相关论文
共 14 条
[11]   18-OXOSTRYCHNINE [J].
SCHEUER, PJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1960, 82 (01) :193-197
[12]   METABOLISM OF DRUGS .41. METABOLIC FATE OF STRYCHNINE IN RABBIT LIVER [J].
TSUKAMOTO, H ;
YOSHIMURA, H ;
WATABE, T ;
OGURI, K .
JOURNAL OF BIOCHEMISTRY, 1964, 55 (04) :394-&
[13]   C-13 NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY OF NATURALLY OCCURRING SUBSTANCES .56. STRYCHNOS ALKALOIDS [J].
WENKERT, E ;
CHEUNG, HTA ;
GOTTLIEB, HE ;
KOCH, MC ;
RABARON, A ;
PLAT, MM .
JOURNAL OF ORGANIC CHEMISTRY, 1978, 43 (06) :1099-1105
[14]  
1986, JAPANESE PHARMACOPOE, P875