ABNORMAL ACCUMULATION OF PHOSPHOLIPASE C-DELTA IN FILAMENTOUS INCLUSIONS OF HUMAN NEURODEGENERATIVE DISEASES

被引：24

作者：

SHIMOHAMA, S

PERRY, G

RICHEY, P

TAKENAWA, T

WHITEHOUSE, PJ

MIYOSHI, K

SUENAGA, T

MATSUMOTO, S

NISHIMURA, M

KIMURA, J

机构：

[1] UNIV TOKYO,INST MED,DEPT ONCOBIOL,MINATO KU,TOKYO 108,JAPAN

[2] HYOGO MED SCH,DEPT PSYCHIAT,NISHINOMIYA,HYOGO 663,JAPAN

[3] KITANO HOSP,DEPT NEUROL,KITA KU,OSAKA 530,JAPAN

[4] CASE WESTERN RESERVE UNIV HOSP,INST PATHOL,DIV NEUROPATHOL,CLEVELAND,OH 44106

[5] CASE WESTERN RESERVE UNIV HOSP,DEPT NEUROL,CLEVELAND,OH 44106

来源：

NEUROSCIENCE LETTERS | 1993年 / 162卷 / 1-2期

关键词：

PHOSPHOLIPASE C-DELTA; ALZHEIMERS DISEASE; PICKS DISEASE; PROGRESSIVE SUPRANUCLEAR PALSY; DIFFUSE LEWY BODY DISEASE; PARKINSONS DISEASE; IMMUNOCYTOCHEMISTRY;

D O I：

10.1016/0304-3940(93)90591-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have previously demonstrated that an antibody to phosphoinositide-specific phospholipase C (PLC) isozyme, PLC-delta, intensely stained neurofibrillary tangles (NFT) in the brain tissue of Alzheimer's disease (AD). This study was performed to determine if abnormal PLC-delta accumulation might be present in the filamentous inclusions of other neurodegenerative diseases. We found that the anti-PLC-delta antibody stained neuronal inclusions of Pick's disease, progressive supranuclear palsy and diffuse Lewy body disease while the inclusions of idiopathic Parkinson's disease lacked PLC-delta accumulation. These results suggest a possible role for PLC-delta interaction in the formation of intraneuronal filamentous inclusions in human neurodegenerative diseases.

引用

页码：183 / 186

页数：4

共 9 条

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Acta Neuropathologica, 2008, 116 : 205 - 213
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SHIMOHAMA, S
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BRAIN PATHOLOGY, 2010, 20 (02) : 281 - 297
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MOLECULAR CARCINOGENESIS, 1994, 11 (04) : 192 - 196

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