PHARMACOKINETICS, BIOCHEMICAL-MECHANISM AND MUTATION ACCUMULATION - A COMPREHENSIVE MODEL OF CHEMICAL CARCINOGENESIS

被引:36
作者
CONOLLY, RB
REITZ, RH
CLEWELL, HJ
ANDERSEN, ME
机构
[1] DOW CHEM CO,MAMMALIAN & ENVIRN TOXICOL,MIDLAND,MI 48640
[2] ARMSTRONG AEROSP MED RES LAB,DIV TOXIC HAZARDS,WRIGHT PATTERSON AFB,OH
关键词
D O I
10.1016/0378-4274(88)90028-8
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
引用
收藏
页码:189 / 200
页数:12
相关论文
共 27 条
[1]   PHYSIOLOGICALLY BASED PHARMACOKINETICS AND THE RISK ASSESSMENT PROCESS FOR METHYLENE-CHLORIDE [J].
ANDERSEN, ME ;
CLEWELL, HJ ;
GARGAS, ML ;
SMITH, FA ;
REITZ, RH .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1987, 87 (02) :185-205
[2]  
ANDERSEN ME, 1987, DRINKING WATER HLTH, V8, P8
[3]   NEOPLASTIC TRANSFORMATION INDUCED BY A DIRECT PERTURBATION OF DNA [J].
BARRETT, JC ;
TSUTSUI, T ;
TSO, POP .
NATURE, 1978, 274 (5668) :229-232
[4]  
Bischoff K. B., 1966, CHEM ENG PROG S, V62, P33
[5]  
DARNELL J, 1986, MOL CELL BIOL, P138
[6]  
DELAIGLESIA FA, 1975, TOXICOLOGY, V4, P305
[7]   CHEMICAL LIVER CARCINOGENESIS - MONITORING OF THE PROCESS BY FLOW CYTOMETRIC DNA MEASUREMENTS [J].
DIGERNES, V .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1983, 50 (APR) :195-200
[8]  
ELMORE E, 1983, CANCER RES, V43, P1650
[9]   THE 1ST RELEVANT CELL STAGE IN RAT-LIVER CARCINOGENESIS - A QUANTITATIVE APPROACH [J].
EMMELOT, P ;
SCHERER, E .
BIOCHIMICA ET BIOPHYSICA ACTA, 1980, 605 (02) :247-304
[10]  
FREIDBERG EC, 1985, DNA REPAIR, P23