CYTOTOXIC EFFECTS OF ACTIVATED HUMAN-MONOCYTES AND LYMPHOCYTES TO ANTI-D-TREATED HUMAN-ERYTHROCYTES INVITRO

被引：19
|
作者：
RANDAZZO, B [1 ]
HIRSCHBERG, T [1 ]
HIRSCHBERG, H [1 ]
机构：
[1] NATL HOSP NORWAY,RIKSHOSP,TISSUE TYPING LAB,OSLO,NORWAY
来源：
SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1979年 / 9卷 / 04期
关键词：
D O I：
10.1111/j.1365-3083.1979.tb03173.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Incuhation of human monocylcs, derived from peripheral blood, with cell‐free supernalants from mixed lymphocyle cultures resulted in mcirpholngical and funelional changes in the mature macropliages. Activation of monocyle‐derived macrophages by these faciors resulted in a significant increase in their capacity to lyse anti‐D‐trealed human erythrticytcs. The tytic activity of both normal and activated macrophages appeared to be independent of eryihrophagocytosis. T lymphocytes activated by either allogeneic cells or ihe mitogen phytohaemagglutinin were not cytolytic lo treated eryihrocytes even at high effector to target cell ratios. Copyright © 1979, Wiley Blackwell. All rights reserved
引用
收藏
页码：351 / 358
页数：8
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