ACTION OF COLCHICINE AND CYTOCHALASIN-B ON THE ACETYLCHOLINE-RECEPTOR

被引：8
作者：
ANWYL, R [1 ]
NARAHASHI, T [1 ]
机构：
[1] NORTHWESTERN UNIV,SCH MED,DEPT PHARMACOL,CHICAGO,IL 60611
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 1979年 / 65卷 / 03期
关键词：
D O I：
10.1111/j.1476-5381.1979.tb07855.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of colchicine and cytochalasin B have been investigated on the extrajunctional acetylcholine (ACh) receptors of rat muscle. Colchicine and cytochalasin B each decreased the amplitude and rise time of the iontophoretic ACh potential. When the dose of ACh was increased in the presence of these agents, ACh potentials were produced with a biphasic waveform consisting of a fast initial phase and a second slow phase. It is proposed that colchicine and cytochalasin B are acting through a mechanism other than the breakdown of microtubules and microfilaments. 1979 British Pharmacological Society
引用
收藏
页码：483 / 488
页数：6
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