ACTION OF COLCHICINE AND CYTOCHALASIN-B ON THE ACETYLCHOLINE-RECEPTOR

被引：8

作者：

ANWYL, R ^{[1
]}

NARAHASHI, T ^{[1
]}

机构：

[1] NORTHWESTERN UNIV,SCH MED,DEPT PHARMACOL,CHICAGO,IL 60611

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1979年 / 65卷 / 03期

关键词：

D O I：

10.1111/j.1476-5381.1979.tb07855.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of colchicine and cytochalasin B have been investigated on the extrajunctional acetylcholine (ACh) receptors of rat muscle. Colchicine and cytochalasin B each decreased the amplitude and rise time of the iontophoretic ACh potential. When the dose of ACh was increased in the presence of these agents, ACh potentials were produced with a biphasic waveform consisting of a fast initial phase and a second slow phase. It is proposed that colchicine and cytochalasin B are acting through a mechanism other than the breakdown of microtubules and microfilaments. 1979 British Pharmacological Society

引用

页码：483 / 488

页数：6

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