ACTION OF COLCHICINE AND CYTOCHALASIN-B ON THE ACETYLCHOLINE-RECEPTOR

被引：8
|
作者：
ANWYL, R [1 ]
NARAHASHI, T [1 ]
机构：
[1] NORTHWESTERN UNIV,SCH MED,DEPT PHARMACOL,CHICAGO,IL 60611
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 1979年 / 65卷 / 03期
关键词：
D O I：
10.1111/j.1476-5381.1979.tb07855.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of colchicine and cytochalasin B have been investigated on the extrajunctional acetylcholine (ACh) receptors of rat muscle. Colchicine and cytochalasin B each decreased the amplitude and rise time of the iontophoretic ACh potential. When the dose of ACh was increased in the presence of these agents, ACh potentials were produced with a biphasic waveform consisting of a fast initial phase and a second slow phase. It is proposed that colchicine and cytochalasin B are acting through a mechanism other than the breakdown of microtubules and microfilaments. 1979 British Pharmacological Society
引用
收藏
页码：483 / 488
页数：6
相关论文
共 50 条
  • [1] INHIBITION OF INTERFERON ACTION BY CYTOCHALASIN-B, COLCHICINE, AND VINBLASTINE
    BOURGEADE, MF
    CHANY, C
    PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 1976, 153 (03): : 501 - 504
  • [2] MORPHOLOGICAL TRANSFORMATION OF BLEPHARISMA BY ACTION OF COLCHICINE, VINBLASTINE AND CYTOCHALASIN-B - NEW BIOLOGICAL ACTION OF COLCHICINE AND VINBLASTINE
    ABE, S
    JOURNAL OF THE AGRICULTURAL CHEMICAL SOCIETY OF JAPAN, 1978, 52 (04): : 151 - 157
  • [3] EFFECTS OF CYTOCHALASIN-B AND COLCHICINE ON COLONIC RESTITUTION
    ROWE, PH
    HANLEY, C
    MASON, RC
    GUT, 1988, 29 (10) : A1484 - A1484
  • [4] THE SITE OF ACTION OF CYTOCHALASIN-B
    SASAKI, J
    IMANAKA, M
    ENDO, T
    KANDA, S
    OTSUKA, N
    ACTA HISTOCHEMICA ET CYTOCHEMICA, 1981, 14 (01) : 86 - 86
  • [5] COMPARATIVE EFFECTS OF CYTOCHALASIN-B AND COLCHICINE ON LETTUCE SEEDLINGS
    SAWHNEY, VK
    SRIVASTAVA, LM
    ANNALS OF BOTANY, 1977, 41 (171) : 271 - &
  • [6] EFFECTS OF CYTOCHALASIN-B AND COLCHICINE ON POLARIZATION OF ODONTOBLASTS AND AMELOBLASTS
    KARCHERDJURICIC, V
    RUCH, JV
    LESOT, H
    JOURNAL OF DENTAL RESEARCH, 1975, 54 (03) : 663 - 663
  • [7] EFFECTS OF CYTOCHALASIN-B AND COLCHICINE ON DENTAL CYTODIFFERENTIATION INVITRO
    RUCH, JV
    KARCHERDJURICIC, V
    STAUBLI, A
    FABRE, M
    ARCHIVES D ANATOMIE MICROSCOPIQUE ET DE MORPHOLOGIE EXPERIMENTALE, 1975, 64 (02): : 113 - 134
  • [8] EFFECT OF CYTOCHALASIN-B AND COLCHICINE ON HUMAN MONOCYTE FUNCTION
    RINEHART, J
    BOULWARE, T
    CLINICAL RESEARCH, 1976, 24 (03): : A317 - A317
  • [9] MECHANISM OF ACTION OF CYTOCHALASIN-B ON ACTIN
    MACLEANFLETCHER, S
    POLLARD, TD
    CELL, 1980, 20 (02) : 329 - 341
  • [10] EFFECTS OF CYTOCHALASIN-B AND CYTOCHALASIN-D AND COLCHICINE ON MIGRATION OF THE CORNEAL EPITHELIUM
    GIPSON, IK
    WESTCOTT, MJ
    BROOKSBY, NG
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1982, 22 (05) : 633 - 642
12345