CA2+-DEPENDENT CARBOHYDRATE-RECOGNITION DOMAINS IN ANIMAL PROTEINS

被引：221
|
作者：
DRICKAMER, K
机构：
[1] Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1993年 / 3卷 / 03期
关键词：
D O I：
10.1016/S0959-440X(05)80112-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Many Ca2+-dependent (C-type) animal lectins contain a common sequence motif, with 14 invariant and 18 highly conserved residues distributed over discrete carbohydrate-recognition domains of 115-130 amino acids. Domains that display the C-type carbohydrate-recognition domain motif are found in an increasing number of proteins, although only some are known to bind carbohydrate. Progress is being made towards making deductions about the structure and activity of these domains from their sequences.
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页码：393 / 400
页数：8
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