STS MAP OF GENES AND ANONYMOUS DNA FRAGMENTS ON HUMAN CHROMOSOME-18 USING A PANEL OF SOMATIC-CELL HYBRIDS

被引：35
作者：
OVERHAUSER, J
MEWAR, R
ROJAS, K
LIA, K
KLINE, AD
SILVERMAN, GA
机构：
[1] THOMAS JEFFERSON UNIV,DIV MED GENET,PHILADELPHIA,PA 19107
[2] HARVARD UNIV,SCH MED,DEPT PEDIAT,JOINT PROGRAM NEONATOL,BOSTON,MA 02115
来源：
GENOMICS | 1993年 / 15卷 / 02期
关键词：
D O I：
10.1006/geno.1993.1072
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Somatic cell hybrids containing different deleted regions of chromosome 18 derived from patients with balanced translocations or terminal deletions were used to create a deletion mapping panel. Twenty-four sequence-tagged sites (STSs) for 17 genes and 7 anonymous polymorphic DNA fragments were identified. These STSs were used to map the 24 loci to 18 defined regions of chromosome 18. Both ERV1, previously mapped to 18q22-q23, and YES1, previously mapped to 18q21.3, were found to map to 18p11.21-pter. Several genes previously mapped to 18q21 were found to be in the order cen-SSAV1-DCC-FECH-GRP-BCL2-PLANH2-tel. The precise mapping of genes to chromosome 18 should help in determining whether these genes may be involved in the etiology of specific chromosomal syndromes associated with chromosome 18. The mapping of the polymorphic loci will assist in the integration of the physical map with the recombination map of chromosome 18. © 1993 Academic Press. All rights reserved.
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页码：387 / 391
页数：5
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