2,4-DIAMINO-5-BENZYLPYRIMIDINES AND ANALOGS AS ANTI-BACTERIAL AGENTS .3. C-BENZYLATION OF AMINOPYRIDINES WITH PHENOLIC MANNICH-BASES - SYNTHESIS OF 1-DEAZA AND 3-DEAZA ANALOGS OF TRIMETHOPRIM

被引：12

作者：

RAUCKMAN, BS ^{[1
]}

ROTH, B ^{[1
]}

机构：

[1] BURROUGHS WELLCOME CO,WELLCOME RES LABS,RES TRIANGLE PK,NC 27709

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1980年 / 23卷 / 04期

关键词：

D O I：

10.1021/jm00178a008

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：384 / 391

页数：8

共 31 条

[1] PURIFICATION AND PROPERTIES OF ESCHERICHIA-COLI DIHYDROFOLATE-REDUCTASE [J].

BACCANARI, D ;

PHILLIPS, A ;

SMITH, S ;

SINSKI, D ;

BURCHALL, J .

BIOCHEMISTRY, 1975, 14 (24) :5267-5273

[2]

Baker BR, 1967, DESIGN ACTIVE SITE D

[3] SIMPLE PYRIMIDINES .3. THE METHYLATION AND STRUCTURE OF THE AMINOPYRIMIDINES [J].

BROWN, DJ ;

HOERGER, E ;

MASON, SF .

JOURNAL OF THE CHEMICAL SOCIETY, 1955, :4035-4040

[4]

BURCHALL JJ, 1965, MOL PHARMACOL, V1, P126

[5] ELECTRICAL EFFECTS OF ORTHO-SUBSTITUENTS IN PYRIDINES + QUINOLINES [J].

CHARTON, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (10) :2033-&

[6] ON MECHANISM OF FOLIC ACID REDUCTASE INHIBITION [J].

COLLIN, R ;

PULLMAN, B .

BIOCHIMICA ET BIOPHYSICA ACTA, 1964, 89 (02) :232-&

[7]

Fox B.A., 1973, ORG SYNTH, V5, P346

[8]

HITCHINGS GH, 1979, S P ENZYME INHIBITOR

[9]

KOGL F, 1948, RECL TRAV CHIM PAYS, V67, P129

[10]

MATTHEWS DA, 1978, J BIOL CHEM, V253, P6946

← 1 2 3 4 →