ESTIMATION OF GENETIC DISTANCES BETWEEN REELER AND NEARBY LOCI ON MOUSE CHROMOSOME-5

被引：17
作者：
DERNONCOURT, C
RUELLE, D
GOFFINET, AM
机构：
[1] Department of Physiology, FUNDP School of Medicine, B-5000 Namur, 61, Rue de Bruxelles
来源：
GENOMICS | 1991年 / 11卷 / 04期
关键词：
D O I：
10.1016/0888-7543(91)90049-K
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Genetic distances between reeler (gene symbol rl) and the adjacent loci Pgy-1, Sor, and En-2 on proximal chromosome 5 were estimated using a backcross panel between rlOrl rlOrl BALB c and C57 mice. Pgy-1 and Sor are located ≈7 cM away from and centromeric to reeler, whereas En-2 is located distally, ≈8 cM from reeler. Backcrosses between rlOrl rlOrl BALB c and mice with the T31H translocation showed that the breakpoint is located less than 2 cM from reeler. Together with previous work, these observations suggest the following gene order: Cen- Sor Pgy-1-rl-T31H-En-2-other loci. © 1991.
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页码：1167 / 1169
页数：3
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