Pulmonary Edema Triggered by Amlodipine

Multiple drugs can cause non-cardiogenic acute pulmonary edema. Most of the time, establishing this causal relationship is very difficult due to low reported incidence of drug adverse effects and non specific symptoms. Peripheral edema is a common side effect of amlodipine; but only two cases of pulmonary edema caused by amlodipine have been published in the literature and both occurred in the context of drug overdose. We describe a unique case of pulmonary edema probably induced by amlodipine at therapeutic doses and we discuss the possible pathophysiological mechanism.