PHARMACOKINETIC MODELING OF PLASMA AND CEREBROSPINAL-FLUID METHOTREXATE AFTER HIGH-DOSE INTRAVENOUS-INFUSION IN CHILDREN

被引：14
作者：
CHATELUT, E
ROCHE, H
PLUSQUELLEC, Y
PEYRILLE, F
DEBIASI, J
PUJOL, A
CANAL, P
HOUIN, G
机构：
[1] CTR INTERDISCIPLINAIRE ETUDES PHARMACOCINET TOULOUSE,TOULOUSE,FRANCE
[2] UNIV TOULOUSE 3,UFR MATH,F-31062 TOULOUSE,FRANCE
[3] CTR CLAUDIUS REGAUD,UNITE PHARMACOL & PHARMACOCINET CLIN,F-31052 TOULOUSE,FRANCE
[4] CHR PURPAN,UNITE PHARMACOCINET,TOULOUSE,FRANCE
[5] CHR PURPAN,SERV PEDIAT,TOULOUSE,FRANCE
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 1991年 / 80卷 / 08期
关键词：
D O I：
10.1002/jps.2600800804
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A pharmacokinetic study was performed in plasma and cerebrospinal fluid (CSF) of patients suffering from brain tumors to describe the disposition of methotrexate. An open three-compartment model was developed to fit together the data obtained in plasma and CSF. The pharmacokinetic parameters obtained by the model agreed with those obtained with classical analysis and the fitting correctly depicted the plasma and CSF concentration decays. According to the results, such a model could be applied to other anticancer drugs.
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收藏
页码：730 / 734
页数：5
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