OSTEOPOROSIS AND DIABETES - LESSONS FROM THE DIABETIC BB RAT

被引：29
作者：
VERHAEGHE, J
VISSER, WJ
EINHORN, TA
BOUILLON, R
机构：
[1] CATHOLIC UNIV LEUVEN,DEPT OBSTET & GYNECOL,B-3000 LOUVAIN,BELGIUM
[2] CATHOLIC UNIV LEUVEN,EXPTL MED & ENDOCRINOL LAB,B-3000 LOUVAIN,BELGIUM
[3] CLIN RES GRP BONE METAB,UTRECHT,NETHERLANDS
[4] CUNY MT SINAI SCH MED,DEPT ORTHOPED,NEW YORK,NY 10029
来源：
HORMONE RESEARCH | 1990年 / 34卷 / 5-6期
关键词：
BB RAT; BONE FORMATION; BONE MINERAL; DIABETES; OSTEOPOROSIS;
D O I：
10.1159/000181834
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The spontaneously diabetic BB rat was used to study the effect of diabetes on bone. Short-term diabetes (3-4 weeks) resulted in a state of low bone turnover, characterized by a severe decrease in osteoblast/osteoid surface and bone mineral apposition rate on histology, and in serum osteocalcin concentrations. If diabetes was long-term (12 weeks), the parameters of low bone formation were associated with histological evidence of osteoporosis and a decreased bone strength; the relative bone calcium concentration remained normal in diabetes. We conclude that long-standing diabetes results in a low-turnover osteoporosis.
引用
收藏
页码：245 / 248
页数：4
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