OSTEOPOROSIS AND DIABETES - LESSONS FROM THE DIABETIC BB RAT

被引：28

作者：

VERHAEGHE, J

VISSER, WJ

EINHORN, TA

BOUILLON, R

机构：

[1] CATHOLIC UNIV LEUVEN,DEPT OBSTET & GYNECOL,B-3000 LOUVAIN,BELGIUM

[2] CATHOLIC UNIV LEUVEN,EXPTL MED & ENDOCRINOL LAB,B-3000 LOUVAIN,BELGIUM

[3] CLIN RES GRP BONE METAB,UTRECHT,NETHERLANDS

[4] CUNY MT SINAI SCH MED,DEPT ORTHOPED,NEW YORK,NY 10029

来源：

HORMONE RESEARCH | 1990年 / 34卷 / 5-6期

关键词：

BB RAT; BONE FORMATION; BONE MINERAL; DIABETES; OSTEOPOROSIS;

D O I：

10.1159/000181834

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The spontaneously diabetic BB rat was used to study the effect of diabetes on bone. Short-term diabetes (3-4 weeks) resulted in a state of low bone turnover, characterized by a severe decrease in osteoblast/osteoid surface and bone mineral apposition rate on histology, and in serum osteocalcin concentrations. If diabetes was long-term (12 weeks), the parameters of low bone formation were associated with histological evidence of osteoporosis and a decreased bone strength; the relative bone calcium concentration remained normal in diabetes. We conclude that long-standing diabetes results in a low-turnover osteoporosis.

引用

页码：245 / 248

页数：4

共 19 条

[1]

ALBRIGHT F, 1948, PARATHYROID GLANDS M, P150

[2] MINERAL METABOLISM AND BONE MASS AT PERIPHERAL AND AXIAL SKELETON IN DIABETES-MELLITUS [J].