RELEASE OF CALCITONIN GENE-RELATED PEPTIDE (CGRP) FROM CAPSAICIN-SENSITIVE VASODILATOR NERVES IN THE RAT MESENTERIC-ARTERY

被引：30
作者：
FUJIMORI, A
SAITO, A
KIMURA, S
GOTO, K
机构：
[1] UNIV TSUKUBA, INST BASIC MED SCI, DEPT PHARMACOL, SAKURA, IBARAKI 305, JAPAN
[2] UNIV TSUKUBA, INST BASIC MED SCI, DEPT BIOCHEM, SAKURA, IBARAKI 305, JAPAN
来源：
NEUROSCIENCE LETTERS | 1990年 / 112卷 / 2-3期
关键词：
Calcitonin gene-related peptide; Capsaicin; Capsaicin-sensitive nerve; Neuropeptide release; Perivascular nerve stimulation; Rat mesenteric artery;
D O I：
10.1016/0304-3940(90)90198-I
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effect of perivascular nerve stimulation (PNS) and capsaicin treatment on the release of calcitonin gene-related peptide (CGRP) was examined by radioimmunoassay (RIA) in isolated, perfused rat mesenteric arteries. In the preparation precontracted by methoxamine and treated with guanethidine, an adrenergic neuron blocker, PNS and capsaicin induced vasodilator responses and increase of CGRP-like immunoreactivity (CGRP-LI) in the perfusate in a frequency-dependent manner. The CGRP-LI released by capsaicin was identified as CGRP and its oxidized form by high-performance liquid chromatography coupled with RIA. After the tissue was treated with capsaicin, PNS didn't cause both the vasodilator response and the increase of CGRP-LI in the perfusate. These findings suggest that CGRP plays a neurotransmitter role in capsaicin-sensitive vasodilator nerves in rat mesenteric arteries. © 1990.
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页码：173 / 178
页数：6
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