COMPUTER-SIMULATION OF TABLET MOTION IN COATING DRUM

被引：48

作者：

YAMANE, K ^{[1
]}

SATO, T ^{[1
]}

TANAKA, T ^{[1
]}

TSUJI, Y ^{[1
]}

机构：

[1] TAIHO PHARMACEUT CO LTD,DEPT QUAL CONTROL,TOKUSHIMA 77001,JAPAN

来源：

PHARMACEUTICAL RESEARCH | 1995年 / 12卷 / 09期

关键词：

COATING DRUM; TABLET MOTION; COMPUTER SIMULATION; SURFACE TIME; CIRCULATION TIME;

D O I：

10.1023/A:1016201102355

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Purpose. The purpose is to develop a new method of finding optimal conditions in tablet coating operations with the use of computer simulation. Methods. DEM(Discrete Element Method), which calculates trajectories of individual tablets by numerically integrating Newton's equations of motion, was used in this simulation. Results. The effects of tablet size, tablet loading, rotation speed on mean surface time, circulation time, and surface time deviation agree qualitatively with experimental results by other workers. Conclusions. It is found that DEM is a useful method of predicting tablet motion in a coating drum.

引用

页码：1264 / 1268

页数：5

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