Inflammatory Mediators in Diabetic Neuropathy

被引：25
作者：
Wilson, Natalie M. [1 ]
Wright, Douglas E. [1 ]
机构：
[1] Univ Kansas, Med Ctr, Dept Anat & Cell Biol, Kansas City, KS 66160 USA
来源：
JOURNAL OF DIABETES & METABOLISM | 2012年 / 3卷
关键词：
D O I：
10.4172/2155-6156.S5-004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Diabetic neuropathy (DN) is the most common complication of diabetes mellitus, resulting in high health care costs and greatly affecting the quality of life of patients. The mechanism(s) responsible for the development of DN is currently unclear, but is likely multifactoral. While a great deal is still unknown about the mediators responsible for the development of DN, current knowledge of other neuropathic conditions suggest the involvement of a number of inflammatory mediators such as interleukins and chemokines. This review will outline the current literature of a number of inflammatory mediators in both human and rodent studies. As there is currently no therapeutic treatment for DN, this review will also provide an overview of therapeutics targeting inflammation and the ability of these therapies to improve the symptoms of DN.
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页数：6
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共 42 条
[11]   Monocytes from type 2 diabetic patients have a pro-inflammatory profile -: 1,25-Dihydroxyvitamin D3 works as anti-inflammatory [J].
Giulietti, Annapaula ;
van Etten, Evelyne ;
Overbergh, Lut ;
Stoffels, Katinka ;
Bouillon, Roger ;
Mathieu, Chantal .
DIABETES RESEARCH AND CLINICAL PRACTICE, 2007, 77 (01) :47-57
[12]   Chemokine (C-C Motif) Ligand 2 (CCL2) in Sera of Patients with Type 1 Diabetes and Diabetic Complications [J].
Guan, Ruili ;
Purohit, Sharad ;
Wang, Hongjie ;
Bode, Bruce ;
Reed, John Chip ;
Steed, R. Dennis ;
Anderson, Stephen W. ;
Steed, Leigh ;
Hopkins, Diane ;
Xia, Chun ;
She, Jin-Xiong .
PLOS ONE, 2011, 6 (04)
[13]   Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy [J].
Hingtgen, Shawn D. ;
Tian, Xin ;
Yang, Jusan ;
Dunlay, Shannon M. ;
Peek, Andrew S. ;
Wu, Yihe ;
Sharma, Ram V. ;
Engelhardt, John F. ;
Davisson, Robin L. .
PHYSIOLOGICAL GENOMICS, 2006, 26 (03) :180-191
[14]   Protective effects of cyclooxygenase-2 gene inactivation against peripheral nerve dysfunction and intraepidermal nerve fiber loss in experimental diabetes [J].
Kellogg, Aaron P. ;
Wiggin, Tim D. ;
Larkin, Dennis D. ;
Hayes, John M. ;
Stevens, Martin J. ;
Pop-Busui, Rodica .
DIABETES, 2007, 56 (12) :2997-3005
[15]   Peripheral nerve dysfunction in experimental diabetes is mediated by cyclooxygenase-2 and oxidative stress [J].
Kellogg, AP ;
Pop-Busui, R .
ANTIOXIDANTS & REDOX SIGNALING, 2005, 7 (11-12) :1521-1529
[16]   Intrathecally administered COX-2 but not COX-1 or COX-3 inhibitors attenuate streptozotocin-induced mechanical hyperalgesia in rats [J].
Matsunaga, Aki ;
Kawamoto, Masashi ;
Shiraishi, Seiji ;
Yasuda, Toshimichi ;
Kajiyama, Seiji ;
Kurita, Shigeaki ;
Yuge, Osafumi .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2007, 554 (01) :12-17
[17]   Urinary tumour necrosis factor-α excretion independently correlates with clinical markers of glomerular and tubulointerstitial injury in type 2 diabetic patients [J].
Navarro, Juan F. ;
Mora, Carmen ;
Muros, Mercedes ;
Garcia, Javier .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2006, 21 (12) :3428-3434
[18]   Significance of chemokines and activated platelets in patients with diabetes [J].
Nomura, S ;
Shouzu, A ;
Omoto, S ;
Nishikawa, M ;
Fukuhara, S .
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2000, 121 (03) :437-443
[19]   Chemokines and glycoprotein 120 produce pain hypersensitivity by directly exciting primary nociceptive neurons [J].
Oh, SB ;
Tran, PB ;
Gillard, SE ;
Hurley, RW ;
Hammond, DL ;
Miller, RJ .
JOURNAL OF NEUROSCIENCE, 2001, 21 (14) :5027-5035
[20]   Pro- and anti-inflammatory cytokine gene expression in rat sciatic nerve chronic constriction injury model of neuropathic pain [J].
Okamoto, K ;
Martin, DP ;
Schmelzer, JD ;
Mitsui, Y ;
Low, PA .
EXPERIMENTAL NEUROLOGY, 2001, 169 (02) :386-391
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