NERVOUS CONTROL OF DISTENSION-INDUCED RELAXATION OF THE PORCINE LOWER ESOPHAGEAL SPHINCTER

被引:4
作者
LUNDELL, L [1 ]
MALBERT, CH [1 ]
ANVARI, M [1 ]
YU, P [1 ]
JAMIESON, GG [1 ]
机构
[1] UNIV ADELAIDE,ROYAL ADELAIDE HOSP,DEPT SURG,ADELAIDE,SA 5001,AUSTRALIA
关键词
ESOPHAGEAL DISTENSION; GASTRIC DISTENSION; LOWER ESOPHAGEAL SPHINCTER; BASAL PRESSURE; SPHINCTER RELAXATION; VAGOTOMY;
D O I
10.1159/000200901
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The mechanisms involved in the relaxation of the lower oesophageal sphincter induced by distension of the oesophagus and different parts of the stomach, were studied in an anaesthetized porcine model. A computer technique was developed allowing on-line digitizing of lower oesophageal sphincter (sleeve device) and intragastric pressures. Basal sphincter tone was slightly reduced by truncal vagotomy, an effect which seemed to be reversed by sectioning of the vagosympathetic trunks in the neck. Balloon distension of the body of the oesophagus, relaxed the sphincter irrespective of the denervation procedures carried out. Distension of the whole stomach with increasing amounts of air induced a dose-dependent relaxatory lower oesophageal sphincter response, which was also closely associated with the subsequent increases in intragastric pressure. Denervation procedures did not alter this dose-response relationship. The importance of intramural mechanisms was illustrated by the abolition of distension-induced effects in most animals studied after transection of the gastro-oesophageal junction distal to the sphincter. Balloon distension of the antrum elicited a smaller but significant sphincter relaxation, but the mechanisms behind this response seemed to be more complex than after insufflation of air.
引用
收藏
页码:217 / 225
页数:9
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