THE MOLECULAR-BASIS OF ALLOREACTIVITY

被引：278

作者：

LECHLER, RI ^{[1
]}

LOMBARDI, G ^{[1
]}

BATCHELOR, JR ^{[1
]}

REINSMOEN, N ^{[1
]}

BACH, FH ^{[1
]}

机构：

[1] UNIV MINNESOTA,DEPT LAB MED & PATHOL,IMMUNOBIOL RES CTR,MINNEAPOLIS,MN 55455

来源：

IMMUNOLOGY TODAY | 1990年 / 11卷 / 03期

关键词：

D O I：

10.1016/0167-5699(90)90033-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The strength of the immune response to foreign histocompatibility molecules has long puzzled immunologists. In this article Robert Lechler and colleagues propose that (1) allorecognition is structurally heterogeneous and varies according to the responder and stimulator MHC types, (2) in closely related combinations the focus of the alloreactive T cell may be on epitopes of endogenous peptides that are displayed by stimulator but not by responder MHC molecules, seen in a 'self-restricted' manner, and (3) in more disparate combinations the alloresponse may be directed primarily against residues on the allogeneic MHC molecule itself. © 1990.

引用

页码：83 / 88

页数：6

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