MICROBIAL STEREO-DIFFERENTIATING REDUCTION OF THE CARBONYL GROUPS LOCATED ON THE C2 AXES OF GYROCHIRAL MOLECULES

被引：30

作者：

NAKAZAKI, M

CHIKAMATSU, H

NAEMURA, K

NISHINO, M

MURAKAMI, H

ASAO, M

机构：

[1] Department of Chemistry, Faculty of Engineering Science, Osaka University, Toyonaka

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 25期

关键词：

D O I：

10.1021/jo00393a028

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantiomer selectivity of Curvularia lunata and Rhodotorula rubra with respect to some C2 ketone substrates having the C2 axis coincident with the carbonyl axis was examined. Both microbes exhibited a marked stereodifferentiation between enantiomers of (.+-.)-9-twist-brendanone, (.+-.)-2-brexanone, (.+-.)-D3-trishomocubanone (8), (.+-.)-bisnoradamantanone, (.+-.)-biphenyl, and (.+-.)-.alpha.-binaphthyl bridged ketones, selectively reducing the P-C2 ketone enantiomers.

引用

页码：4588 / 4593

页数：6

共 33 条

[1]

BENTLEY R, 1970, MOL ASYMMETRY BIOL, V2, P41

[2] SPECIFICATION OF MOLECULAR CHIRALITY [J].