MET-ENKEPHALIN AND LEU-ENKEPHALIN IMMUNOREACTIVITY IN SEPARATE NEURONS

被引：122

作者：

LARSSON, LI ^{[1
]}

CHILDERS, S ^{[1
]}

SNYDER, SH ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21205

来源：

NATURE | 1979年 / 282卷 / 5737期

关键词：

D O I：

10.1038/282407a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A pair of pentapeptides, Met- and Leu-enkephalin were recently isolated from brain tissue1,2. The two peptides seem to represent endogenous opiate receptor ligands and have by immunocytochemical and radioimmunoassay studies been shown to occur in an extensive system of cerebral and peripheral nerves3-8. The relative proportions between Met- and Leu-enkephalin varies between different brain regions and also between different species, suggesting the existence of separate populations of Met- and Leu-enkephalin nerves9-12. Until now, however, immunocytochemistry has given no support for this notion. We report here evidence of separate populations of Met-and Leu-enkephalin nerves. © 1979 Nature Publishing Group.

引用

页码：407 / 410

页数：4

共 22 条

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[6] IDENTIFICATION OF 2 RELATED PENTAPEPTIDES FROM BRAIN WITH POTENT OPIATE AGONIST ACTIVITY [J].

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[7] RADIOIMMUNOCYTOCHEMISTRY - NOVEL IMMUNOCYTOCHEMICAL PRINCIPLE [J].

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JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1977, 25 (10) :1140-1146

[8] CHARACTERIZATION OF ANTRAL GASTRIN CELLS WITH REGION-SPECIFIC ANTISERA [J].

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[9]

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[10] ENDOGENOUS OPIOID PEPTIDES - MULTIPLE AGONISTS AND RECEPTORS [J].

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