SEROTONIN AND THE BIOLOGY OF FEEDING

被引：113

作者：

BLUNDELL, JE

机构：

[1] BioPsychology Group, Psychology Department, University of Leeds, Leeds

[2] BioPsychology Group, Psychology Department, University of Leeds

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 1992年 / 55卷 / 01期

关键词：

SEROTONIN; APPETITE CONTROL; SATIETY; ANOREXIA; NUTRITION; RECEPTORS; DIET;

D O I：

10.1093/ajcn/55.1.155s

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

There is good evidence that the experimental manipulation of serotonin causes changes in feeding behavior and that adjustments in feeding and in the nutritional supply bring about responses in the level or activity of serotonin. These data suggest that 5-HT systems in the body mediate nutritional input and the drive to feed. In addition, it is known that serotonin is a phylogenetically primitive neurotransmitter, which may therefore occupy a central role in the relationship between food and brain organization. A framework can be developed by considering the interrelationships among feeding processes (operations of the satiety cascade), peripheral physiological mechanisms, and brain serotonin systems. Two key issues are how nutritional information is transcribed onto brain 5-HT systems and the nature of this information. The neuroanatomical distribution of 5-HT neurons occupy an appropriate position in which to coordinate peripheral physiological and metabolic information, environmental features, and the behavioral response.

引用

页码：155 / 159

页数：5

共 65 条

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