A QUICK ONE-POT SYNTHESIS OF SPIROINDOLINE DERIVATIVES USING 1,3-DIBROMO-5,5-DIMETHYLHYDANTOIN

被引：0

作者：

Hojati, S. F. ^{[1
]}

Mohamadi, S. ^{[1
]}

MoeiniEghbali, N. ^{[1
]}

Raouf, H. ^{[1
]}

机构：

[1] Hakim Sabzevari Univ, Dept Chem, Sabzevar 9617976487, Iran

来源：

HETEROCYCLIC LETTERS | 2018年 / 8卷 / 01期

关键词：

Heterocycles; Multi-component reactions; Spiroindoline; One-pot synthesis;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel multi-component reaction for synthesis of spiro[indoline3,4'-pyrano[2,3-c]pyrazole] derivatives is reported herein. 1,3-Dibromo-5,5-dimethylhydantoin is found to catalyze efficiently the four-component one-pot condensation of isatin, malononitrile, ethyl acetoacetate and hydrazine hydrate to afford a wide range of spiro[indoline3,4'-pyrano[2,3-c]pyrazole] derivativesin good yields. The use of a 1,3-Dibromo-5,5-dimethylhydantoin catalyst makes this method simple, convenient, and cost-effective.

引用

页码：19 / 25

页数：7

共 22 条

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