AN HMG-BOX-CONTAINING T-CELL FACTOR REQUIRED FOR THYMOCYTE DIFFERENTIATION

被引:430
作者
VERBEEK, S
IZON, D
HOFHUIS, F
ROBANUSMAANDAG, E
TERIELE, H
VANDEWETERING, M
OOSTERWEGEL, M
WILSON, A
MACDONALD, HR
CLEVERS, H
机构
[1] UNIV UTRECHT HOSP,DEPT IMMUNOL,3508 GA UTRECHT,NETHERLANDS
[2] NETHERLANDS CANC INST,DIV IMMUNOL,1066 CX AMSTERDAM,NETHERLANDS
[3] NETHERLANDS CANC INST,DIV MOLEC GENET,1066 CX AMSTERDAM,NETHERLANDS
[4] UNIV LAUSANNE,LUDWIG INST CANC RES,CH-1066 EPALINGES,SWITZERLAND
关键词
D O I
10.1038/374070a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Two candidate genes for controlling thymocyte differentiation, T-cell factor-1 (Tcf-1) and lymphoid enhancer-binding factor (Lef-1), encode closely related DNA-binding HMG-box proteins(1,2). Their expression pattern is complex and largely overlapping during embryogenesis, yet restricted to lymphocytes postnatally(3). Here we generate two independent germline mutations in Tcf-1 and find that thymocyte development is (otherwise normal) mutant mice is blocked at the transition from the CD8(+), immature single-positive to the CD4(+)/CD8(+) double-positive stage. Is contrast to wild-type mice, most of the immature single-positive cells in the mutants are not in the cell cycle and the number of immunocompetent T cells in peripheral lymphoid organs is reduced. We conclude that Tcf-1 controls an essential step in thymocyte differentiation.
引用
收藏
页码:70 / 74
页数:5
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