THE IRS-1 SIGNALING SYSTEM

被引：296
|
作者：
MYERS, MG [1 ]
SUN, XJ [1 ]
WHITE, MF [1 ]
机构：
[1] HARVARD UNIV,SCH MED,PROGRAM CELL & DEV BIOL,BOSTON,MA 02215
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 07期
关键词：
D O I：
10.1016/0968-0004(94)90007-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Insulin-receptor substrate 1 (IRS-1) is a principal substrate of the receptor tyrosine kinase for insulin and insulin-like growth factor 1, and a substrate for a tyrosine kinase activated by interleukin 4. IRS-1 undergoes multisite tyrosine phosphorylation and mediates downstream signals by 'docking' various proteins that contain Src homology 2 domains. IRS-1 appears to be a unique molecule; however, 4PS, a protein found mainly in hemopoietic cells, may represent another member of this family.
引用
收藏
页码：289 / 293
页数：5
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