TETRAHYDROAMINOACRIDINE (THA) REDUCES VOLTAGE-DEPENDENT CALCIUM CURRENTS IN RAT SENSORY NEURONS

被引：16

作者：

KELLY, KM ^{[1
]}

GROSS, RA ^{[1
]}

MACDONALD, RL ^{[1
]}

机构：

[1] UNIV MICHIGAN,MED CTR,DEPT PHYSIOL,ANN ARBOR,MI 48104

来源：

NEUROSCIENCE LETTERS | 1991年 / 132卷 / 02期

关键词：

TETRAHYDROAMINOACRIDINE; TACRINE; ALZHEIMERS DISEASE; CALCIUM CURRENT; WHOLE CELL PATCH CLAMP;

D O I：

10.1016/0304-3940(91)90312-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Tetrahydroaminoacridine (THA) is a centrally active anticholinesterase that also interacts with neuronal K+ and Na+ channels and cardiac Ca2+ channels. The effects of THA on neuronal voltage-dependent Ca2+ channels are not known. We tested the effects of THA (25 nM-250-mu-M) on the Ca2+ current components of acutely dissociated rat nodose ganglion and dorsal root ganglion (DRG) neurons using the whole cell patch clamp recording technique. THA reduced the low-threshold (T) and high-threshold (N/L) Ca2+ current components in a concentration-dependent manner (IC50 congruent-to 125-mu-M for T; congruent-to 80-mu-M for N/L). Minimal current reduction was seen below approximately 10-mu-M. Our results show that THA reduces voltage-dependent Ca2+ currents in rodent sensory neurons suggesting another means by which THA may affect Ca2+-dependent physiologic processes.

引用

页码：247 / 250

页数：4

共 22 条

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[2] KINETICS AND SELECTIVITY OF A LOW-VOLTAGE-ACTIVATED CALCIUM CURRENT IN CHICK AND RAT SENSORY NEURONS [J].