Acute toxicity in patients with localized prostate cancer treated with high dose of Intensity Modulated Radiotherapy

Introduction: the prostate cancer is the most common of male sex to worldwide level. In the 2006 year were estimated 234,460 new cases in USA, and in this same year was to third cause of death with 27,350 cases. According to the last RHNM (Histopatology report of malignant neoplasia) in 2005, the incidence of this cancer in Mexico was the number one in men over age 65 with 4,026 cases. That previous, so with tumor biology and radio biologic behavior this neoplasia is good reasons that exist actually a therapeutic diversity enlarges. Thereby establish a challenge in this moment to medicine. In the last three decade, the treatments with radiotherapy have undergone o great change: from conventional radiotherapy to three-dimensional conformal radiation therapy (RTC-3D) and Intensity Modulated Radiotherapy (IMRT) now; this technique has allowed irradiate a high dose on tumoral tissue without toxicity increase. Objective: Determine the acute toxicity in patients with localized prostate cancer treated with radical radiotherapy of intensity modulated. Material and Methods: The study Included 40 patients in a lapse to encompass from to August of 2005 to August 2008 with localized prostate cancer. The treatment was with radiotherapy with radical purpose, 21 patients received conformal radiotherapy and 19 patients intensity modulated. Acute toxicity genitourinary and gastrointestinal was determining utilized chi2 test. Results: The genitourinary toxicity was greater in the group that received conformal radiotherapy; the gastrointestinal was same in both groups. Only have grade I-II toxicity to accord modified scale to RTOG 9406. Conclusions: Intensity modulated radiotherapy reduced to acute toxicity, whereas in this moment is the best option therapeutic in patients with localized prostate cancer.