CONTACTS OF THE GLOBULAR DOMAIN OF HISTONE H5 AND CORE HISTONES WITH DNA IN A CHROMATOSOME

被引：78
|
作者：
HAYES, JJ
PRUSS, D
WOLFFE, AP
机构：
[1] Laboratory of Molecular Embryology, NICHHD, National Institutes of Health, Bethesda
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 16期
关键词：
NUCLEOSOME; CHROMATIN; 5S RIBOSOMAL-RNA GENE; XENOPUS;
D O I：
10.1073/pnas.91.16.7817
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The globular domain of histone H5 is found to asymmetrically associate with a nucleosome core including the Xenopus borealis somatic 5S RNA gene. Histones H2A and H2B are required for association of histone H5. Strong crosslinking of the globular domain of histone H5 to the 5S DNA in the nucleosome occurs at a single site to one side of the dyad axis. This site is also in contact with the core histones, and the interactions of the core histones with 5S DNA change as a result of association of the globular domain of histone H5. We discuss evidence for an allosteric change in core histone-5S DNA interactions following the association of the linker histone in the nucleosome.
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收藏
页码：7817 / 7821
页数：5
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