A TOTAL SYNTHESIS OF 6,7-DIHYDROEPONEMYCIN AND DETERMINATION OF STEREOCHEMISTRY OF THE EPOXIDE RING

被引：11

作者：

HOSHI, H

OHNUMA, T

ABURAKI, S

KONISHI, M

OKI, T

机构：

[1] Bristol-Myers Squibb, Research Institute, Meguro-ku, Tokyo, 153

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(00)77488-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A total synthesis of 6,7-dihydroeponemycin 2 was achieved vis the epoxide, intermediate 8a. Unresolved absolute configuration of the epoxide ring in 2 and eponemycin 1 was determined to be 2R by application of the asymmetric Sharpless epoxidation of 9.

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页码：1047 / 1050

页数：4

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