SYNTHESIS OF (+)-NOJIRIMYCIN AND (-)-NOJIRIMYCIN AND THEIR 1-DEOXY DERIVATIVES FROM MYOINOSITOL

被引：31

作者：

CHIDA, N ^{[1
]}

FURUNO, Y ^{[1
]}

IKEMOTO, H ^{[1
]}

OGAWA, S ^{[1
]}

机构：

[1] KEIO UNIV,FAC SCI & TECHNOL,DEPT APPL CHEM,KOHOKU KU,YOKOHAMA,KANAGAWA 223,JAPAN

来源：

CARBOHYDRATE RESEARCH | 1992年 / 237卷

关键词：

D O I：

10.1016/S0008-6215(92)84242-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The conversion of the naturally abundant cyclitol, myo-inositol (4), into (+)-nojirimycin (1a), its enantiomer (1b), and their 1-deoxy analogues (2a and 2b) is described. Biological assay of 2a, 2b, and the bisulfite adducts of 1a and 1b (3a and 3b) showed that the compounds having the unnatural L-gluco configuration (2b and 3b) possess moderate-to-high inhibitory activity against almond beta-D-glucosidase and bovine liver beta-D-galactosidase.

引用

页码：185 / 194

页数：10

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