PHOSPHOLIPID N-METHYLATION IN DIABETIC ERYTHROCYTES - EFFECTS ON MEMBRANE NA+, K+ ATPASE ACTIVITY

被引：4

作者：

KOWLURU, A ^{[1
]}

KOWLURU, RA ^{[1
]}

机构：

[1] LOS ALAMOS NATL LAB,DIV LIFE SCI,MOLEC & CELL BIOL GRP,LOS ALAMOS,NM 87545

来源：

CELL BIOCHEMISTRY AND FUNCTION | 1992年 / 10卷 / 02期

关键词：

PHOSPHOLIPID METHYLATION; STREPTOZOTOCIN DIABETES; ERYTHROCYTE NA+; K+; ATPASE;

D O I：

10.1002/cbf.290100205

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phospholipid methylation was quantified in non-diabetic and streptozotocin diabetic rat erythrocytes. While the total mass of methylated lipids remained the same in both groups, the relative abundance of individual methylated lipid species differed significantly in diabetic erythrocytes. Moreover. incubation of erythrocytes membranes with S-adenosyl methionine, a substrate for methyl transferases, not only increased membrane lipid methylation but also decreased Na+, K+ ATPase activity significantly. These results suggest that phospholipid methylation may cause the observed depression of erythrocyte Na+, K+ ATPase activity in diabetes and could contribute to the altered rheology of erythrocytes in diabetes.

引用

页码：95 / 101

页数：7

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