PT-195 AND H-1-NMR STUDIES OF PLATINUM(II) COMPLEXES WITH ETHYLENEDIAMINE DERIVATIVES

Complexes of the types Pt(L)Cl2, [Pt(L)(D2O)2](NO3)2, [Pt(L)(D2O)(NO3)](NO3), Pt(L)(OD)2, [Pt(L)(D2O)Cl]+ and Pt(L)(OD)Cl, where L = ethylenediamine, N,N-dimethylethylenediamine, N,N'-dimethylethylenediamine and N,N,N',N'-tetramethylethylenediamine, were characterized mainly by Pt-195 and H-1 (high- and low-field) nuclear magnetic resonance. The NMR spectra were measured in D2O. The dichloro complexes showed a Pt-195 resonance between -2355 and -2433 ppm (relative to Na2PtCl6) whereas the diaqua compounds absorbed at lower field from -1821 to -1977 ppm. The signals of the monoaqua-monochloro species were observed at intermediate field between -2030 and -2173 ppm. The dihydroxo complexes showed a resonance at lower field (about 100 ppm) than the diaqua compounds, whereas the monochloro-monohydroxo species absorbed at about 50 ppm from the monoaqua-monochloro species. The monoaqua-mononitrato compounds with only two ligands absorbed at about -20 ppm from the diaqua species. The high-field proton NMR spectra of the complexes were also measured. The Pt-195-H-1 coupling constants were obtained from the low-field proton NMR spectra.