ZONE-SPECIFIC HEPATOTOXICITY OF GOSSYPOL IN PERFUSED-RAT-LIVER

被引：10

作者：

MANABE, S ^{[1
]}

NUBER, DC ^{[1
]}

LIN, YC ^{[1
]}

机构：

[1] SANKYO CO LTD,LAB ANIM SCI & TOXICOL LABS,FUKUROI,SHIZUOKA 437,JAPAN

来源：

TOXICON | 1991年 / 29卷 / 06期

关键词：

D O I：

10.1016/0041-0101(91)90071-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Gossypol selectively damages the periportal region of lobules in perfused rat liver, while retrograde perfusion caused pericentral liver damage. Moreover, the addition of 0.4% bovine serum albumin(BSA) to the perfusate completely prevented the toxic effect of gossypol on hepatocytes, decreasing the absorption of gossypol by the liver. This study indicates that the damage caused by gossypol depends upon the direction of exposure and can be protected against by its binding to BSA.

引用

页码：787 / 790

页数：4

共 23 条

[1]

AMADOR E, 1963, CLIN CHEM, V9, P391

[2]

BADR MZ, 1986, J PHARMACOL EXP THER, V238, P1138

[3]

BELINSKY SA, 1984, J PHARMACOL EXP THER, V230, P755

[4]

BELINSKY SA, 1984, MOL PHARMACOL, V25, P158

[5]

COUTINHO EM, 1984, FERTIL STERIL, V42, P424

[6]

CRAIG WA, 1983, HDB CLIN PHARMACOKIN, P55

[7]

FRICK J, 1985, GOSSYPOL POTENTIAL C, P17

[8] INHIBITORY EFFECT OF GOSSYPOL ON STEROIDOGENIC PATHWAYS IN CULTURED BOVINE LUTEAL CELLS [J].

GU, Y ;

LIN, YC ;

RIKIHISA, Y .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 169 (02) :455-461

[9]

HADLEY MA, 1981, J ANDROL, V2, P190

[10]

HASPEL HC, 1984, J PHARMACOL EXP THER, V299, P218

← 1 2 3 →