RAPID DECREASE IN BRAIN ENKEPHALIN CONTENT AFTER LOW-DOSE WHOLE-BODY X-IRRADIATION OF THE RAT

被引：6

作者：

MIYACHI, Y ^{[1
]}

OGAWA, N ^{[1
]}

MORI, A ^{[1
]}

机构：

[1] OKAYAMA UNIV,SCH MED,INST NEUROBIOL,DEPT NEUROCHEM,OKAYAMA 700,JAPAN

来源：

JOURNAL OF RADIATION RESEARCH | 1992年 / 33卷 / 01期

关键词：

ENKEPHALIN; LOW-DOSE; NEUROTRANSMITTER; CENTRAL NERVOUS SYSTEM; RADIOSENSITIVITY;

D O I：

10.1269/jrr.33.11

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Methionine-enkephalin (ME) contents in the hypothalamus and other rat brain structures were measured immediately after 10 or 20 cGy whole-body X-irradiation. TheME contents of homogenates of the striatum, hypothalamus, midbrain + thalamus, hindbrain and pituitary were assayed radioimmunologically with I-125. The contents of all the structures, except the pituitary, decreased significantly after 20 cGy irradiation. the reduction in the hypothalamus was transient. ME content gradually recovering with time. These results suggest that the central nervous system of mammals is one of the most radiosensitive organs as judged by changes in stress-induced mediators such as ME.

引用

页码：11 / 15

页数：5

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