MOLECULAR-CLONING OF 25-HYDROXYVITAMIN-D-3 24-HYDROXYLASE (CYP-24) FROM MOUSE KIDNEY - ITS INDUCIBILITY BY VITAMIN-D-3

被引：23

作者：

ITOH, S

YOSHIMURA, T

IEMURA, O

YAMADA, E

TSUJIKAWA, K

KOHAMA, Y

MIMURA, T

机构：

[1] Division of Bio-Medical and Immunological Chemistry, Faculty of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565, 1-6, Yamadaoka

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1995年 / 1264卷 / 01期

关键词：

CDNA CLONING; CYP24; CYTOCHROME-P-450; 1-ALPHA; 25-DIHYDROXYVITAMIN-D-3; VITAMIN-D-3;

D O I：

10.1016/0167-4781(95)00147-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cDNA encoding a 25-hydroxyvitamin D-3 24-hydroxylase, Cyp-24. has been isolated from mouse kidney cDNA library by hybridization screening. Mouse Cyp-24, coding for 514 amino acid residues. shared 82.1 and 94.7% amino acid identity with human and rat CYP24s, respectively. Among mouse organs examined, Cyp-24 mRNA could be detected in the kidney. When mice were treated with vitamin D-3, Cyp-24 mRNA was induced in the kidney.

引用

页码：26 / 28

页数：3

共 3 条

[1] CLONING AND EXPRESSION OF CDNA-ENCODING 25-HYDROXYVITAMIN-D3 24-HYDROXYLASE
OHYAMA, Y
NOSHIRO, M
OKUDA, K
FEBS LETTERS, 1991, 278 (02) : 195 - 198
[2] Cloning and expression of the chicken 25-hydroxyvitamin D3 24-hydroxylase cDNA
Jehan, F
Ismail, R
Hanson, K
DeLuca, HF
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1998, 1395 (03): : 259 - 265
[3] MOLECULAR-CLONING OF CDNA FOR VITAMIN-D3 25-HYDROXYLASE FROM RAT-LIVER MITOCHONDRIA
USUI, E
NOSHIRO, M
OKUDA, K
FEBS LETTERS, 1990, 262 (01) : 135 - 138

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