ENANTIOSELECTIVE ENZYMATIC-SYNTHESIS OF THE ANTIVIRAL AGENT LAMIVUDINE (3TC(TM))

被引：54
作者：
MILTON, J
BRAND, S
JONES, MF
RAYNER, CM
机构：
[1] UNIV LEEDS, SCH CHEM, LEEDS LS2 9JT, W YORKSHIRE, ENGLAND
[2] GLAXO RES & DEV LTD, CHEM DEV, STEVENAGE SG1 2NY, HERTS, ENGLAND
来源：
TETRAHEDRON LETTERS | 1995年 / 36卷 / 38期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1016/0040-4039(95)01380-Z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel enzymatic resolution of alpha-acetoxysulfides has been used as the key step in the synthesis of the important antiviral nucleoside analogue lamivudine. The synthesis proceeds via a configurationally stable hemithioacetal which cyclises in situ to form the required oxathiolane nucleus, which can then be converted into the target nucleoside in 4 steps.
引用
收藏
页码：6961 / 6964
页数：4
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