Proliferation and differentiation of human fetal brain neural stem cells in vitro

被引：10
|
作者：
McGrath, Erica L. [1 ]
Gao, Junling [1 ]
Wu, Ping [1 ,2 ]
机构：
[1] Univ Texas Med Branch, Dept Neurosci & Cell Biol, Res Bldg 17,Room 4-212 B,301 Univ Blvd, Galveston, TX 77555 USA
[2] Capital Med Univ, Beijing Inst Brain Disorders, Beijing, Peoples R China
来源：
JOURNAL OF NEURORESTORATOLOGY | 2018年 / 6卷
关键词：
neural stem cell; proliferation; differentiation; neuron; astrocyte;
D O I：
10.2147/JN.S148794
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Primary human fetal brain neural stem cells (hNSCs) are a unique non-genetically modified model system to study molecular mechanisms underlying human neural development, to model human diseases, and to screen drugs or validate new treatments. They may also be used for cell transplantation to treat various neurological diseases. This protocol details our methods that can be used to expand hNSCs in culture as well as how to differentiate them into various neuronal lineages and astrocytes.
引用
收藏
页码：19 / 27
页数：9
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