Chronic obstructive pulmonary disease (COPD): Expression of a chronic inflammatory reaction

被引：0
作者：
Ziesche, Rolf [1 ]
机构：
[1] Univ Klin Innere Med IV, Klin Abt Pulmol, Vienna, Austria
来源：
WIENER MEDIZINISCHE WOCHENSCHRIFT | 2005年 / 155卷 / 5-6期
关键词：
COPD; COPD-chronic inflammation; COPD-influence of wound healing;
D O I：
10.1007/s10354-005-0152-x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Our understanding of chronic inflammation in COPD has been profoundly changed as a result of findings which suggest that airway inflammation in COPD consists not only of a chronic cellular inflammatory reaction dominated by lymphocytes and neutrophil granulocytes, but also of an intensified secondary wound healing reaction. Unfortunately, little is known about the impact of both reactions on the maintenance of chronic airway inflammation in COPD. Systematic biological evaluation under clinical circumstances will be necessary in order to realize new therapeutic options in COPD.
引用
收藏
页码：81 / 84
页数：4
相关论文
共 8 条
  • [1] Asthma - From bronchoconstriction to airways inflammation and remodeling
    Bousquet, J
    Jeffery, PK
    Busse, WW
    Johnson, M
    Vignola, AM
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 161 (05) : 1720 - 1745
  • [2] Molecular regulation of lung development
    Cardoso, WV
    [J]. ANNUAL REVIEW OF PHYSIOLOGY, 2001, 63 : 471 - 494
  • [3] Office spirometry for lung health assessment in adults - A consensus statement from the National Lung Health Education Program
    Ferguson, GT
    Enright, PL
    Buist, AS
    Higgins, MW
    [J]. CHEST, 2000, 117 (04) : 1146 - 1161
  • [4] Clinical significance of respiratory bronchiolitis on open lung biopsy and its relationship to smoking related interstitial lung disease
    Moon, J
    du Bois, RM
    Colby, TV
    Hansell, DM
    Nicholson, AG
    [J]. THORAX, 1999, 54 (11) : 1009 - 1014
  • [5] CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease
    Saetta, M
    Di Stefano, A
    Turato, G
    Facchini, FM
    Corbino, L
    Mapp, CE
    Maestrelli, P
    Ciaccia, A
    Fabbri, LM
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 157 (03) : 822 - 826
  • [6] Goblet cell hyperplasia and epithelial inflammation in peripheral airways of smokers with both symptoms of chronic bronchitis and chronic airflow limitation
    Saetta, M
    Turato, G
    Baraldo, S
    Zanin, A
    Braccioni, F
    Mapp, CE
    Maestrelli, P
    Cavallesco, G
    Papi, A
    Fabbri, LM
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 161 (03) : 1016 - 1021
  • [7] Increased expression of inflammatory mediators in small-airway epithelium from tobacco smokers
    Takizawa, H
    Tanaka, M
    Takami, K
    Ohtoshi, T
    Ito, K
    Satoh, M
    Okada, Y
    Yamasawa, F
    Umeda, A
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2000, 278 (05) : L906 - L913
  • [8] Do lung remodeling, repair, and regeneration recapitulate respiratory ontogeny?
    Warburton, D
    Tefft, D
    Mailleux, A
    Bellusci, S
    Thiery, JP
    Zhao, JS
    Buckley, S
    Shi, W
    Driscoll, B
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 164 (10) : S59 - S62
1