ANTIBIOTIC-TREATMENT OF YERSINIA-ENTEROCOLITICA SEPTICEMIA - A RETROSPECTIVE REVIEW OF 43 CASES

被引:60
|
作者
GAYRAUD, M
SCAVIZZI, MR
MOLLARET, HH
GUILLEVIN, L
HORNSTEIN, MJ
机构
[1] UNIV PARIS NORD, HOP AVICENNE, SERV BACTERIOL VIROL, 125 ROUTE STALINGRAD, F-93009 BOBIGNY, FRANCE
[2] UNIV PARIS NORD, HOP AVICENNE, SERV MED INTERNE, F-93009 BOBIGNY, FRANCE
[3] INST PASTEUR, UNITE ECOL BACTERIENNE, F-75724 PARIS 15, FRANCE
关键词
D O I
10.1093/clinids/17.3.405
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Of 53 documented cases of Yersinia enterocolitica septicemia reported to the French national registry between 1985 and 1991, 43 files contained sufficient information on antibiotic treatment to be analyzed retrospectively. All patients had at least two positive cultures of blood collected before the initiation of treatment. All strains were susceptible in vitro to the antibiotics that are usually active against gram-negative rods except for older beta-lactam agents (i.e., aminopenicillins and first-generation cephalosporins). No multiresistant strain was isolated. Only four (7.5%) of the 53 patients died. Aminopenicillins, first-generation cephalosporins, and-when prescribed alone-amoxicillin/clavulanate were not effective. Third-generation cephalosporins, most often used in combination with other antibiotics, were successful in 85% of cases. Fluoroquinolones-alone or in combination-cured all of 15 infections, with patients improving rapidly and becoming apyretic within 1-4 days. These agents therefore seem to constitute the best treatment.
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页码:405 / 410
页数:6
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