EXPRESSION OF XENOBIOTIC-METABOLIZING CYTOCHROME-P450 FORMS IN HUMAN ADULT AND FETAL LIVER

被引：162

作者：

HAKKOLA, J

PASANEN, M

PURKUNEN, R

SAARIKOSKI, S

PELKONEN, O

MAENPAA, J

RANE, A

RAUNIO, H

机构：

[1] UNIV KUOPIO,DEPT PHARMACOL & TOXICOL,SF-90721 KUOPIO,FINLAND

[2] UNIV KUOPIO,DEPT OBSTET & GYNAECOL,SF-90721 KUOPIO,FINLAND

[3] UPPSALA UNIV,AKAD HOSP,DEPT CLIN PHARMACOL,S-75185 UPPSALA,SWEDEN

来源：

BIOCHEMICAL PHARMACOLOGY | 1994年 / 48卷 / 01期

关键词：

CYTOCHROME P450; XENOBIOTIC; HUMAN LIVER; FETUS; PCR;

D O I：

10.1016/0006-2952(94)90223-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Expression of human cytochrome P450 (CYP) genes in human adult and fetal liver were studied using the reverse transcriptase-polymerase chain reaction (RT-PCR) method. In adult liver mRNA of CYPs 1A1, 1A2, 2A6/2A7, 2B6/2B7, 2C8-19, 2D6, 2E1, 3A3/3A4 and 3A7 were detected while CYPs 2F1 and 4B1 were absent. In fetal liver mRNA of CYPs 2C8, 2D6, 3A3/3A4 and 3A7 were found but all other forms studied were undetectable. The results provide a comprehensive qualitative picture of the expression of CYP genes in families CYP1 through CYP4 in human adult and fetal liver.

引用

页码：59 / 64

页数：6

共 42 条

[31] COMPARISON OF HUMAN FETAL HEPATIC AND ADRENAL CYTOCHROME-P450 ACTIVITIES WITH SOME MAJOR GESTATIONAL STEROIDS AND ETHYLMORPHINE AS SUBSTRATES [J].