EXPRESSION OF XENOBIOTIC-METABOLIZING CYTOCHROME-P450 FORMS IN HUMAN ADULT AND FETAL LIVER

被引：162
作者：
HAKKOLA, J
PASANEN, M
PURKUNEN, R
SAARIKOSKI, S
PELKONEN, O
MAENPAA, J
RANE, A
RAUNIO, H
机构：
[1] UNIV KUOPIO,DEPT PHARMACOL & TOXICOL,SF-90721 KUOPIO,FINLAND
[2] UNIV KUOPIO,DEPT OBSTET & GYNAECOL,SF-90721 KUOPIO,FINLAND
[3] UPPSALA UNIV,AKAD HOSP,DEPT CLIN PHARMACOL,S-75185 UPPSALA,SWEDEN
来源：
BIOCHEMICAL PHARMACOLOGY | 1994年 / 48卷 / 01期
关键词：
CYTOCHROME P450; XENOBIOTIC; HUMAN LIVER; FETUS; PCR;
D O I：
10.1016/0006-2952(94)90223-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Expression of human cytochrome P450 (CYP) genes in human adult and fetal liver were studied using the reverse transcriptase-polymerase chain reaction (RT-PCR) method. In adult liver mRNA of CYPs 1A1, 1A2, 2A6/2A7, 2B6/2B7, 2C8-19, 2D6, 2E1, 3A3/3A4 and 3A7 were detected while CYPs 2F1 and 4B1 were absent. In fetal liver mRNA of CYPs 2C8, 2D6, 3A3/3A4 and 3A7 were found but all other forms studied were undetectable. The results provide a comprehensive qualitative picture of the expression of CYP genes in families CYP1 through CYP4 in human adult and fetal liver.
引用
收藏
页码：59 / 64
页数：6
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