COMPARISON OF VIRULENCE BETWEEN SEOUL VIRUS-STRAIN SR-11 AND HANTAAN VIRUS-STRAIN 76-118 OF HANTAVIRUSES IN NEWBORN MICE

被引：24

作者：

YOO, YC ^{[1
]}

YOSHIMATSU, K ^{[1
]}

YOSHIDA, R ^{[1
]}

TAMURA, M ^{[1
]}

AZUMA, I ^{[1
]}

ARIKAWA, J ^{[1
]}

机构：

[1] HOKKAIDO UNIV,INST IMMUNOL SCI,KITA-15-JO,NISHI-7-CHOME,SAPPORO,HOKKAIDO 060,JAPAN

来源：

MICROBIOLOGY AND IMMUNOLOGY | 1993年 / 37卷 / 07期

关键词：

HANTAVIRUS; HEMORRHAGIC FEVER; VIRULENCE; VIRUS INFECTION; ANIMAL EXPERIMENT;

D O I：

10.1111/j.1348-0421.1993.tb01677.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Virulence of hantavirus strain of SR-11 Seoul virus and Hantaan 76-118 (HTN) of Hantaan virus were compared. Infections of both strains were lethal in newborn mice. However, inoculum required to cause lethal infection was about 4,000 times higher for strain HTN (1.65 x 10(3) PFU/mouse/LD50) than for strain SR-11 (0.36 PFU). Thus, both strains were considered pathogenic to newborn mice but they possessed different levels of virulence. The assay system used for these strains in newborn mice proved to be useful in the study of hantavirus vilurence. Growth curves of the two strains in CV-7 cell cultures were compared. Strain SR-11 was shown to have higher activity of virus replication and virus release into the culture fluids than strain HTN. The possibility of a relationship between replication activity and high levels of virulence in mice was suggested.

引用

页码：557 / 562

页数：6