Significance of F-18-sodium Fluoride Positron Emission Tomography in Characterization of POEMS Osteosclerotic Lesions Better Than F-18-fluorodeoxyglucose Positron Emission Tomography

Crow-Fukase syndrome (POEMS syndrome) is a rare systemic paraneoplastic syndrome. Bone lesions are manifested by sclerotic osteoblastic lesions often associated with bone pain. Characterization of osseous lesions is always crucial for clinical correlation and better patient management. We present a case where F-18-fluorodeoxyglucose positron emission tomography (F-18-FDG PET/CT) was unable to characterize a clinically symptomatic patient, and F-18-fluoride PET/CT showed excellent characterization of osteosclerotic lesions. The results were in correlation with already published data and showed that F-18-fluoride PET/CT has better uptake in osteoblastic lesions in POEMS syndrome when compared to F-18-FDG PET/CT and have superior imaging quality in assessing the bone lesions.