Synthesis and Investigation of the Pharmacological Activity of Oreoselone Nitrogen-Containing Derivatives

被引：0

作者：

Lipeeva, A. V. ^{[1
]}

Shults, E. E. ^{[1
]}

Morozova, E. A. ^{[1
]}

Tolstikova, T. G. ^{[1
]}

Tolstikov, G. A. ^{[1
]}

机构：

[1] Russian Acad Sci, Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Prospekt Akademika Lavrentyeva 9, Novosibirsk 630090, Russia

来源：

CHEMISTRY FOR SUSTAINABLE DEVELOPMENT | 2010年 / 18卷 / 04期

关键词：

furocoumarins; bromoreoselone; 2-(1,3-dibromopropane-2-ylidene)-2I-furo-[3,2-g][1]benzopyran3,7-dione; motion activity; chloral hydrate sleep;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The bromination of peucedanine using different reagents resulted in the formation of 2-bromoreoselone. Via the reaction with the derivatives of pi peridine and piperazine we synthesized 2-piperazino and 2-pi peridino derivatives of oreoselone. Conditions were determined for the formation of 2-(1,3-dibromopropane-2-ylidene)-2H-furo-[3,2-g][1]-benzopyran-3,7-dione. The interaction of the latter with tyramine resulted in obtaining bis(diaminophenethyl) derivative of furocoumarin. The amination of the mentioned dibromide with the help of spermine resulted in the formation of a macrocyclic compound containing both furocoumarin and polyamine fragments. The effect of novel oreoselone derivatives on the central nervous system was investigated.

引用

页码：381 / 388

页数：8

共 17 条

[1]

Bagryanskaya I. A., 2005, KHIM PRIR SOEDIN, V6, P541

[2] Simple coumarins and analogues in medicinal chemistry: Occurrence, synthesis and biological activity [J].